Measuring the transition to homogeneity with photometric redshift surveys

We study the possibility of detecting the transition to homogeneity using photometric redshift catalogs. Our method is based on measuring the fractality of the projected galaxy distribution, using angular distances, and relies only on observable quantites. It thus provides a way to test the Cosmological Principle in a model-independent unbiased way. We have tested our method on different synthetic inhomogeneous catalogs, and shown that it is capable of discriminating some fractal models with relatively large fractal dimensions, in spite of the loss of information due to the radial projection. We have also studied the influence of the redshift bin width, photometric redshift errors, bias, non-linear clustering, and surveyed area, on the angular homogeneity index H2 ({\theta}) in a {\Lambda}CDM cosmology. The level to which an upcoming galaxy survey will be able to constrain the transition to homogeneity will depend mainly on the total surveyed area and the compactness of the surveyed region. In particular, a Dark Energy Survey (DES)-like survey should be able to easily discriminate certain fractal models with fractal dimensions as large as D2 = 2.95. We believe that this method will have relevant applications for upcoming large photometric redshift surveys, such as DES or the Large Synoptic Survey Telescope (LSST).Comment: 14 pages, 14 figure

Reconstrucción de rotura crónica de tendón distal del bíceps braquial: a propósito de un caso

Las roturas inveteradas o crónicas del tendón distal del bíceps braquial son infrecuentes. Su tratamiento supone un reto importante por el grado de retracción y deficiente calidad del tendón y músculo lesionados, que en ocasiones obligan al empleo de injertos para tratar de restaurar la anatomía y mejorar los resultados funcionales. La tasa de complicaciones en las reparaciones de roturas crónicas es mayor con respecto a las reparaciones de lesiones agudas. Presentamos el caso de una reparación quirúrgica de una rotura crónica de 3 meses de evolución mediante la utilización de aloinjerto liofilizado de Aquiles.Chronic or inveterate disruptions of the distal biceps brachii are uncommon. Treatment remains a major challenge by shrinkage and poor quality of the injured tendon and muscle, which sometimes require the use of grafts to try to restore the anatomy and improve the functional outcomes. The rate of complications in surgical treatment of chronic tears is more than the repairs of acute injuries. We report the case of a surgical reconstruction of a chronic tear three months of evolution using lyophilized Achilles allograft

Do hospitals have a higher mortality rate on weekend admissions? An observational study to analyse weekend effect on urgent admissions to hospitals in Catalonia

Background 'Weekend effect' is a term used to describe the increased mortality associated with weekend emergency admissions to hospital, in contrast with admission on weekdays. The objective of the present study is to determine whether the weekend effect is present in hospitals in Catalonia. Methods We analysed all urgent admissions in Catalonia in 2018, for a group of pathologies. Two groups were defined (those admitted on a weekday and those admitted on a weekend). We obtained mortality at 3, 7, 15 and 30 days, and applied a proportions test to both groups. Additionally, we used Cox's regression for mortality at 30 days, using the admission on a weekend as the exposition, adjusting by socioeconomic and clinical variables. We used the hospital discharge database and the Central Registry of the Insured Population. Results 72 427 admissions for the selected pathologies during 2018 were found. No statistically significant differences in mortality at 30 days (p=0.524) or at 15 days (p=0.119) according to the day of admission were observed. However, significant differences were found in mortality at 7 days (p=0.025) and at 3 days (p=0.002). The hazard rate associated with the weekend was 1.13 (95% CI: 1.04 to 1.23). By contrast, the adjusted HR of the weekend interaction with time was 0.99 (95% CI: 0.99 to 1.00). Conclusions There is a weekend effect, but it is not constant in time. This could suggest the existence of dysfunctions in the quality of care during the weekend

Advance directives and real-world end-of-life clinical practice : a case-control study

Background Advance directives (ADs) have been legally regulated to promote autonomy over health decisions among patients who later lose decision-making capacity. Aims and objectives To analyse the differences in clinical practice at end of life among people who had completed an AD versus those who had not. Methods Retrospective case-control study (1:2), matched by age, sex, year, cause of death and region of residence. The data sources used were the ADs registry, central registry of insured persons, hospital discharge, pharmacy and billing databases, and the mortality registry. Conditional logistic regression models (crude and adjusted by socioeconomic level) were performed. The outcome variable was the frequency of medical procedures performed during the last year of life. Results 1723 people with ADs who died in Catalonia during 2014-2015 were matched with 3446 dead controls (without ADs). Thoracentesis was the procedure with the greatest reduction among women with an AD (adjusted OR (OR adj) 0.54, 95% CI: 0.32 to 0.89) in conjunction with artificial nutrition (OR adj 0.54, 95% CI: 0.31 to 0.95). Intubation was the procedure with the greatest reduction (OR adj 0.56, 95% CI: 0.33 to 0.94) among men. Slight differences could be seen in the case of cancer deaths. There were no relevant differences when adjusting by socioeconomic level. Conclusions ADs are an effective tool to adjust the realisation of some procedures at end of life. These results can help better plan for the treatment of patients with ADs, as well as increase the awareness among clinical personnel, families and the general population

An overview of the ciao multiparadigm language and program development environment and its design philosophy

We describe some of the novel aspects and motivations behind the design and implementation of the Ciao multiparadigm programming system. An important aspect of Ciao is that it provides the programmer with a large number of useful features from different programming paradigms and styles, and that the use of each of these features can be turned on and off at will for each program module. Thus, a given module may be using e.g. higher order functions and constraints, while another module may be using objects, predicates, and concurrency. Furthermore, the language is designed to be extensible in a simple and modular way. Another important aspect of Ciao is its programming environment, which provides a powerful preprocessor (with an associated assertion language) capable of statically finding non-trivial bugs, verifying that programs comply with specifications, and performing many types of program optimizations. Such optimizations produce code that is highly competitive with other dynamic languages or, when the highest levéis of optimization are used, even that of static languages, all while retaining the interactive development environment of a dynamic language. The environment also includes a powerful auto-documenter. The paper provides an informal overview of the language and program development environment. It aims at illustrating the design philosophy rather than at being exhaustive, which would be impossible in the format of a paper, pointing instead to the existing literature on the system

Role of Hydroxyl Groups in the Preferential Oxidation of CO over Copper Oxide–Cerium Oxide Catalysts

Model CuO/Ce0.8X0.2Oδ catalysts (with X = Ce, Zr, La, Pr, or Nd) have been prepared in order to obtain CuO/ceria materials with different chemical features and have been characterized by X-ray diffraction, Raman spectroscopy, N2 adsorption, and H2 temperature-programmed reduction. CO-PROX experiments have been performed in a fixed-bed reactor and in an operando DRIFTS cell coupled to a mass spectrometer. The CO oxidation rate over CuO/ceria catalysts correlates with the formation of the Cu+–CO carbonyl above a critical temperature (90 °C for the experimental conditions in this study) because copper–carbonyl formation is the rate-limiting step. Above this temperature, CO oxidation capacity depends on the redox properties of the catalyst. However, decomposition of adsorbed intermediates is the slowest step below this threshold temperature. The hydroxyl groups on the catalyst surface play a key role in determining the nature of the carbon-based intermediates formed upon CO chemisorption and oxidation. Hydroxyls favor the formation of bicarbonates with respect to carbonates, and catalysts forming more bicarbonates produce faster CO oxidation rates than those which favor carbonates.The authors thank the financial support of Generalitat Valenciana (Project PROMETEOII/2014/010 and Grant BEST/2014/250), the Spanish Ministry of Economy and Competitiveness (Projects CTQ2012-30703, CTQ2012-31762, MAT2014-61992-EXP, and Grant PRX14/00249), and the UE (FEDER funding)

Rotura bilateral y simultánea del tendón de Aquiles

La rotura bilateral y simultánea del tendón de Aquiles es un hecho excepcional. La producción de esta lesión en una persona joven, sin antecedentes patológicos ni de administración de ciertos medicamentos es aún más excepcional. El tratamiento quirúrgico y un adecuado proceso de seguimiento y rehabilitación contribuyen a una buena recuperación y pronóstico en los individuos jóvenes y activos con roturas del tendón de Aquiles. Se presenta un caso clínico de una mujer de 21 años tratada quirúrgicamente con buen resultado.The bilateral and simultaneous rupture of Achilles tendon is an excepcional situation. The production of this injury in a young person, without history pathological or administration of certain drugs is even more exceptional. The surgical treatment and a proper process of following-up and rehabilitation help to a good recovery and prognosis in young and active people with Achilles tendon ruptures

¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama?

Introduction: To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. Methods: This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biop-sies. Results: 118 required a complete axillary lymph node dissection (ALNhD). About 35.6% (42/118) had metastases to a NSLN, and 64.4% (76/118) had no metastasis to a NSLN. The ROC curve of the total tumor load (TTL) presented an area under the curve (AUC) of 0.651 (95%; CI: 0.552-0.751). The 7294 copies of CK19 mRNA were established as the optimal cutoff point, with sensitivity: 93%, specificity: 63%, positive predictive value: 44%, and negative predictive value: 91%. By as-sociating the clinicopathological parameters (multicentricity, pooled immunohistochemistry [IHC], and progesterone receptors), the AUC went up to 0.752 (95% CI: 0.663-0.841). Conclusions: Clinicopathological factors should be considered together with the total CK19 mRNA copy number (the TTL) of the SLNs to improve the predictive capacity of metastatic involvement of the NSLNs